Medicine · Projected milestone
Reversible metabolic suppression in humans
30% by 2055 · including earlier years
The year is an editorial timing estimate. The percentage applies to occurrence by the stated deadline. These estimates are not calibrated odds.
A controlled human study safely reduces oxygen consumption beyond a matched cooling-only control for at least twelve hours, reverses the state, and demonstrates a prespecified beneficial clinical endpoint.
Explore this milestone on the interactive mapWhat the forecast means
Milestone stage: clinical validation
torpor-like physiology demonstrated in rodents only
Timing window: 2033–2055. An editorial range, not a statistical confidence interval.
Completion criteria: A controlled human study safely reduces oxygen consumption beyond a matched cooling-only control for at least twelve hours, reverses the state, and demonstrates a prespecified beneficial clinical endpoint. Resolve only from inspectable evidence meeting every stated criterion; a plan or extrapolation does not resolve it.
This page describes a forecast, rather than an achieved result. Read the methodology and assumptions.
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Sources & evidence
- Induction of a torpor-like hypothermic and hypometabolic state in rodents by ultrasound 2023
Ultrasound induced torpor-like physiology in rodents. Translation to humans, safety and therapeutic benefit remain separate questions.
Astra editorial synthesis; cited researchers retain credit for their results
Record reviewed 2026-10-18